{"product_id":"modern-adaptive-randomized-clinical-trials-hardback","title":"Modern Adaptive Randomized Clinical Trials - Hardback","description":"\u003cp\u003e\u003cem\u003eIs adaptive randomization always better than traditional fixed-schedule randomization? Which procedures should be used and under which circumstances? What special considerations are required for adaptive randomized trials? What kind of statistical inference should be used to achieve valid and unbiased treatment comparisons following adaptive randomization designs?\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003eModern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects answers these questions and more. \u003c\/p\u003e\u003cp\u003eFrom novel designs to cutting-edge applications, this book presents several new and key developments in adaptive randomization. It also offers a fresh and critical look at a number of already-classical topics.\u003c\/p\u003e\u003cp\u003eFeaturing contributions from statisticians, clinical trialists, and subject-matter experts in academia and the pharmaceutical industry, the text:\u003c\/p\u003e\u003cul\u003e \u003cli\u003eClarifies the taxonomy of the concept of adaptive randomization\u003c\/li\u003e \u003cli\u003eDiscusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive (CARA) randomization designs, as well as randomized designs with treatment selection\u003c\/li\u003e \u003cli\u003eGives an exposition to many novel adaptive randomization techniques such as brick tunnel randomization, targeted least absolute shrinkage and selection operator (LASSO)-based CARA randomization, multi-arm multi-stage (MAMS) designs, to name a few\u003c\/li\u003e \u003cli\u003eAddresses the issues of statistical inference following covariate-adaptive and response-adaptive randomization designs\u003c\/li\u003e \u003cli\u003eDescribes a successful implementation of a single pivotal phase II\/III adaptive trial in infants with proliferating hemangioma\u003c\/li\u003e \u003cli\u003eExplores some practical aspects of phase II dose-ranging studies and examines statistical monitoring and interim analysis issues in response-adaptive randomized clinical trials\u003c\/li\u003e \u003c\/ul\u003e\u003cp\u003e\u003cb\u003eModern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects \u003c\/b\u003ecovers a wide spectrum of topics related to adaptive randomization designs in contemporary clinical trials. The book provides a thorough exploration of the merits of adaptive randomization and aids in identifying when it is appropriate to apply such designs in practice.\u003c\/p\u003e","brand":"Taylor \u0026 Francis","offers":[{"title":"Default Title","offer_id":45565372268782,"sku":"9781482239881","price":260.8,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0630\/9612\/7726\/files\/9781482239881.jpg?v=1720678164","url":"https:\/\/bookland.com.au\/products\/modern-adaptive-randomized-clinical-trials-hardback","provider":"Book Land AU","version":"1.0","type":"link"}