{"product_id":"genetic-toxicology-and-cancer-risk-assessment-hardback","title":"Genetic Toxicology and Cancer Risk Assessment - Hardback","description":"\u003cp\u003ePresents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!\u003cbr\u003e\u003cbr\u003eThis book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.\u003cbr\u003e\u003cbr\u003eExamines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development\/Environmental Protection Agency guidelines!\u003cbr\u003e\u003cbr\u003eComprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment\u003c\/p\u003e\u003cli\u003ereviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis \u003cbr\u003e \u003c\/li\u003e\u003cli\u003ecalculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens \u003cbr\u003e \u003c\/li\u003e\u003cli\u003ereveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models \u003cbr\u003e \u003c\/li\u003e\u003cli\u003ediscusses the threshold concept of carcinogenesis \u003cbr\u003e \u003c\/li\u003e\u003cli\u003edemonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens \u003cbr\u003e \u003c\/li\u003e\u003cli\u003econsiders structural activity relationship (SAR) analysis of chemical carcinogenicity \u003cbr\u003e \u003c\/li\u003e\u003cli\u003edescribes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays \u003cbr\u003e \u003c\/li\u003e\u003cli\u003eillustrates the use of genetic biomarkers for dosimetry analysis \u003cbr\u003e \u003c\/li\u003e\u003cli\u003eand more!\u003cbr\u003eLinking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.\u003c\/li\u003e","brand":"Taylor \u0026 Francis","offers":[{"title":"Default Title","offer_id":45583191769326,"sku":"9780824702946","price":302.4,"currency_code":"AUD","in_stock":true}],"url":"https:\/\/bookland.com.au\/products\/genetic-toxicology-and-cancer-risk-assessment-hardback","provider":"Book Land AU","version":"1.0","type":"link"}